Hydrochlorothiazide: The most common indications and signs and symptoms of overdose noticed in human beings are These attributable to electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from abnormal diuresis.

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Irbesartan helps prevent angiotensin II binding on the AT1 receptor in tissues like vascular smooth muscle mass and also the adrenal gland. Irbesartan and its active metabolite bind the AT1 receptor with 8500 times much more affinity than they bind for the AT2 receptor.

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Individuals experiencing an overdose may well current with hypokalemia, hypochloremia, and hyponatremia. Treat sufferers with symptomatic and supportive cure including fluids and electrolytes. Vasopressors could possibly be administered to take care of hypotension and oxygen can be given for respiratory impairment.

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Irbesartan's avoidance of angiotensin II binding triggers vascular clean muscle mass relaxation and stops the secretion of aldosterone, decreasing blood pressure level.

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